{"id":11312,"date":"2017-06-28T16:36:09","date_gmt":"2017-06-28T11:06:09","guid":{"rendered":"https:\/\/iihs.co.in\/knowledge-gateway\/?p=11312"},"modified":"2020-12-10T11:11:39","modified_gmt":"2020-12-10T05:41:39","slug":"an-acetylationdeacetylation-cycle-controls-the-export-of-sterols-and-steroids-from-s-cerevisiae","status":"publish","type":"post","link":"https:\/\/iihs.co.in\/knowledge-gateway\/an-acetylationdeacetylation-cycle-controls-the-export-of-sterols-and-steroids-from-s-cerevisiae\/","title":{"rendered":"An Acetylation\/Deacetylation Cycle Controls the Export of Sterols and Steroids from S.cerevisiae"},"content":{"rendered":"<div id='full_slider_1'  class='avia-fullwidth-slider main_color avia-shadow   avia-builder-el-0  el_before_av_layout_row  avia-builder-el-first   container_wrap sidebar_right'  ><div  class='avia-slideshow av-pvah68-d789fdbd6e6cf3e5e1192c9783547bd0 avia-slideshow-featured av_slideshow_full avia-fade-slider av-slideshow-ui av-control-hidden 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class='flex_cell_inner'><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-aabb985e2935bece55810c9d7afcaa81\">\n#top .av-special-heading.av-av_heading-aabb985e2935bece55810c9d7afcaa81{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-av_heading-aabb985e2935bece55810c9d7afcaa81 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-aabb985e2935bece55810c9d7afcaa81 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-aabb985e2935bece55810c9d7afcaa81 av-special-heading-h3  avia-builder-el-5  el_before_av_textblock  avia-builder-el-first '><h3 class='av-special-heading-tag'  itemprop=\"headline\"  >An Acetylation\/Deacetylation Cycle Controls the Export of Sterols and Steroids from S.cerevisiae<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-3trpmi8-0220586a4152aec7434df656c3a1a15c '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span style=\"font-size: 13px; text-transform: none; color: #8a0000;\"><em>Rashi Tiwari, K\u00f6ffel R, Schneiter R\u00a0<\/em>| 2007<\/span><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-3btflcg-be1faec65ec6153ef34a871d9a33f2da '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Abstract<\/p>\n<p>Sterol homeostasis in eukaryotic cells relies on the reciprocal interconversion of free sterols and steryl esters. Here we report the identification of a novel reversible sterol modification in yeast, the sterol acetylation\/deacetylation cycle. Sterol acetylation requires the acetyltransferase ATF2, whereas deacetylation requires SAY1, a membrane-anchored deacetylase with a putative active site in the ER lumen. Lack of SAY1 results in the secretion of acetylated sterols into the culture medium, indicating that the substrate specificity of SAY1 determines whether acetylated sterols are secreted from the cells or whether they are deacetylated and retained. Consistent with this proposition, we find that acetylation and export of the steroid hormone precursor pregnenolone depends on its acetylation by ATF2, but is independent of SAY1-mediated deacetylation. Cells lacking Say1 or Atf2 are sensitive against the plant-derived allylbenzene eugenol and both Say1 and Atf2 affect pregnenolone toxicity, indicating that lipid acetylation acts as a detoxification pathway. The fact that homologues of SAY1 are present in the mammalian genome and functionally substitute for SAY1 in yeast indicates that part of this pathway has been evolutionarily conserved.<\/p>\n<\/div><\/section><br \/>\n<div  class='avia-button-wrap av-2w69o8g-382c4d7a5fd4bd653999741408b645be-wrap avia-button-left  avia-builder-el-8  el_after_av_textblock  el_before_av_hr '><a href='https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18034159' class='avia-button av-2w69o8g-382c4d7a5fd4bd653999741408b645be avia-icon_select-yes-left-icon avia-size-medium avia-position-left avia-color-theme-color' target=\"_blank\" rel=\"noopener noreferrer\"><span class='avia_button_icon avia_button_icon_left' aria-hidden='true' data-av_icon='\ue82d' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Access Paper<\/span><\/a><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2o2ppao-463322b6070f165d282cc0c2bfa7439e\">\n#top 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aria-label=\"Climate Change (10 items)\">Climate Change<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/conference-reports\/\" class=\"tag-cloud-link tag-link-187 tag-link-position-6\" style=\"font-size: 8pt;\" aria-label=\"Conference Reports (1 item)\">Conference Reports<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/cultural-flows\/\" class=\"tag-cloud-link tag-link-200 tag-link-position-7\" style=\"font-size: 8pt;\" aria-label=\"Cultural Flows (1 item)\">Cultural Flows<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/culture\/\" class=\"tag-cloud-link tag-link-107 tag-link-position-8\" style=\"font-size: 14.434782608696pt;\" aria-label=\"Culture (10 items)\">Culture<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/data-and-metrics\/\" class=\"tag-cloud-link tag-link-103 tag-link-position-9\" style=\"font-size: 18.347826086957pt;\" aria-label=\"Data and Metrics (30 items)\">Data and Metrics<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/design\/\" class=\"tag-cloud-link tag-link-145 tag-link-position-10\" style=\"font-size: 11.478260869565pt;\" aria-label=\"Design (4 items)\">Design<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/economic-development\/\" class=\"tag-cloud-link tag-link-99 tag-link-position-11\" style=\"font-size: 18.95652173913pt;\" aria-label=\"Economic Development (35 items)\">Economic Development<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/ecosystem\/\" class=\"tag-cloud-link tag-link-152 tag-link-position-12\" style=\"font-size: 15.826086956522pt;\" aria-label=\"Ecosystem (15 items)\">Ecosystem<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/energy\/\" class=\"tag-cloud-link tag-link-160 tag-link-position-13\" style=\"font-size: 11.478260869565pt;\" aria-label=\"Energy (4 items)\">Energy<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/environment-and-climate\/\" class=\"tag-cloud-link tag-link-104 tag-link-position-14\" style=\"font-size: 22pt;\" aria-label=\"Environment and Climate (80 items)\">Environment and Climate<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/equity\/\" class=\"tag-cloud-link tag-link-94 tag-link-position-15\" style=\"font-size: 9.5652173913043pt;\" aria-label=\"Equity (2 items)\">Equity<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/gender\/\" class=\"tag-cloud-link tag-link-110 tag-link-position-16\" style=\"font-size: 11.478260869565pt;\" aria-label=\"Gender (4 items)\">Gender<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/ghs-pop\/\" class=\"tag-cloud-link tag-link-183 tag-link-position-17\" style=\"font-size: 8pt;\" aria-label=\"GHS-POP (1 item)\">GHS-POP<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/governance\/\" class=\"tag-cloud-link tag-link-102 tag-link-position-18\" style=\"font-size: 18pt;\" aria-label=\"Governance (27 items)\">Governance<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/gynecology-and-obstetrics\/\" class=\"tag-cloud-link tag-link-188 tag-link-position-19\" style=\"font-size: 8pt;\" aria-label=\"Gynecology And Obstetrics (1 item)\">Gynecology And Obstetrics<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/health\/\" class=\"tag-cloud-link tag-link-151 tag-link-position-20\" style=\"font-size: 9.5652173913043pt;\" aria-label=\"Health (2 items)\">Health<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/higher-education\/\" class=\"tag-cloud-link tag-link-195 tag-link-position-21\" style=\"font-size: 8pt;\" aria-label=\"higher education (1 item)\">higher education<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/housing\/\" class=\"tag-cloud-link tag-link-13 tag-link-position-22\" style=\"font-size: 18pt;\" aria-label=\"Housing (27 items)\">Housing<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/human-development\/\" class=\"tag-cloud-link tag-link-100 tag-link-position-23\" style=\"font-size: 15.652173913043pt;\" aria-label=\"Human Development (14 items)\">Human Development<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/india\/\" class=\"tag-cloud-link tag-link-182 tag-link-position-24\" style=\"font-size: 8pt;\" aria-label=\"India (1 item)\">India<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/industrial-policy\/\" class=\"tag-cloud-link tag-link-80 tag-link-position-25\" style=\"font-size: 9.5652173913043pt;\" aria-label=\"Industrial Policy (2 items)\">Industrial Policy<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/institutional-structures\/\" class=\"tag-cloud-link tag-link-197 tag-link-position-26\" style=\"font-size: 8pt;\" aria-label=\"institutional structures (1 item)\">institutional structures<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/instructional-design\/\" class=\"tag-cloud-link tag-link-150 tag-link-position-27\" style=\"font-size: 9.5652173913043pt;\" aria-label=\"Instructional Design (2 items)\">Instructional Design<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/ipcc\/\" class=\"tag-cloud-link tag-link-126 tag-link-position-28\" style=\"font-size: 9.5652173913043pt;\" aria-label=\"IPCC (2 items)\">IPCC<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/knowledge\/\" class=\"tag-cloud-link tag-link-143 tag-link-position-29\" style=\"font-size: 10.608695652174pt;\" aria-label=\"Knowledge (3 items)\">Knowledge<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/land\/\" class=\"tag-cloud-link tag-link-108 tag-link-position-30\" style=\"font-size: 19.565217391304pt;\" aria-label=\"Land (42 items)\">Land<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/non-economic-loss\/\" class=\"tag-cloud-link tag-link-194 tag-link-position-31\" style=\"font-size: 8pt;\" aria-label=\"Non-Economic Loss &quot; (1 item)\">Non-Economic Loss &quot;<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/pedagogy\/\" class=\"tag-cloud-link tag-link-196 tag-link-position-32\" style=\"font-size: 8pt;\" aria-label=\"pedagogy (1 item)\">pedagogy<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/planning\/\" class=\"tag-cloud-link tag-link-106 tag-link-position-33\" style=\"font-size: 17.565217391304pt;\" aria-label=\"Planning (24 items)\">Planning<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/policies\/\" class=\"tag-cloud-link tag-link-146 tag-link-position-34\" style=\"font-size: 10.608695652174pt;\" aria-label=\"Policies (3 items)\">Policies<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/population-mapping\/\" class=\"tag-cloud-link tag-link-184 tag-link-position-35\" style=\"font-size: 8pt;\" aria-label=\"population mapping (1 item)\">population mapping<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/poverty-and-inequality\/\" class=\"tag-cloud-link tag-link-101 tag-link-position-36\" style=\"font-size: 17.391304347826pt;\" aria-label=\"Poverty and Inequality (23 items)\">Poverty and Inequality<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/research-communication\/\" class=\"tag-cloud-link tag-link-199 tag-link-position-37\" style=\"font-size: 8pt;\" aria-label=\"Bet365 लाइव क्रिकेट स्ट्रीमिंग Communication (1 item)\">Bet365 लाइव क्रिकेट स्ट्रीमिंग Communication<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/risk\/\" class=\"tag-cloud-link tag-link-97 tag-link-position-38\" style=\"font-size: 16.521739130435pt;\" aria-label=\"Risk (18 items)\">Risk<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/scholarly-publishing\/\" class=\"tag-cloud-link tag-link-130 tag-link-position-39\" style=\"font-size: 9.5652173913043pt;\" aria-label=\"Scholarly Publishing (2 items)\">Scholarly Publishing<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/science-gaps\/\" class=\"tag-cloud-link tag-link-193 tag-link-position-40\" style=\"font-size: 8pt;\" aria-label=\"Science Gaps (1 item)\">Science Gaps<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/sustainability\/\" class=\"tag-cloud-link tag-link-93 tag-link-position-41\" style=\"font-size: 12.782608695652pt;\" aria-label=\"Sustainability (6 items)\">Sustainability<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/transport\/\" class=\"tag-cloud-link tag-link-95 tag-link-position-42\" style=\"font-size: 12.173913043478pt;\" aria-label=\"Transport (5 items)\">Transport<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/urban-equality\/\" class=\"tag-cloud-link tag-link-198 tag-link-position-43\" style=\"font-size: 8pt;\" aria-label=\"urban equality (1 item)\">urban equality<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/urbanisation\/\" class=\"tag-cloud-link tag-link-88 tag-link-position-44\" style=\"font-size: 12.782608695652pt;\" aria-label=\"Urbanisation (6 items)\">Urbanisation<\/a>\n<a href=\"https:\/\/iihs.co.in\/knowledge-gateway\/tag\/water-and-sanitation\/\" class=\"tag-cloud-link tag-link-96 tag-link-position-45\" style=\"font-size: 17.826086956522pt;\" aria-label=\"Water and Sanitation (26 items)\">Water and Sanitation<\/a><\/div>\n<\/div><\/div><\/p>\n<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p><em>Rashi Tiwari, K\u00f6ffel R, Schneiter R<\/em><\/p>\n<hr\/>\n","protected":false},"author":2,"featured_media":10245,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-11312","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-paper"],"_links":{"self":[{"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/posts\/11312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/comments?post=11312"}],"version-history":[{"count":0,"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/posts\/11312\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/media\/10245"}],"wp:attachment":[{"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/media?parent=11312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/categories?post=11312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/iihs.co.in\/knowledge-gateway\/wp-json\/wp\/v2\/tags?post=11312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}